Infantile Convulsions with Paroxysmal Dyskinesia (ICCA Syndrome) and Copy Number Variation at Human Chromosome 16p11
Figure 3
Two specific subregions (ICCA.SRa and ICCA.SRb) of Variation_7105 were analyzed in nine unrelated ICCA patients (series S1) and in unrelated control individuals. (A) Comparisons of DCt values for ICCA.SRa (left) and ICCA.SRb (right) between ICCA patients and controls. (**) indicates P<0.01. (***) indicates P<0.001. DCt values of the control DNA pool (Promega) used for whole genome CGH array experiments (Cont Pool 1), of the pool of 50 DNAs of control individuals (Cont Pool 2), and of patient II.4 from pedigree E of Chinese origin[3], are also indicated. (B) Clustering analysis of DCt values for ICCA.SRa and ICCA.Srb in ICCA patients (red triangles) and controls (blue dots). Patient II.4 of pedigree E[3] is also indicated (purple square). The two clusters (Cluster 1, pink circle; Cluster 2, brown circle) that could be statistically isolated from all other values are indicated (see also Figure S2).