Differentiation in Neuroblastoma: Diffusion-Limited Hypoxia Induces Neuro-Endocrine Secretory Protein 55 and Other Markers of a Chromaffin Phenotype
Figure 7
Morphological features of NESP55 immunoreactive cells in clinical neuroblastoma and in ganglioneuroma.
A–C: Favourable outcome, stroma-poor infant stage 3 neuroblastoma. Boxed region in panel A is shown in panel C. D: prognostically unfavourable, stroma-poor adolescent stage 4 neuroblastoma. E–H: Stroma-rich ganglioneuroma. G and H show the respective nuclear morphologies of cells indicated in E. Panels A, C, E, G and H are haematoxylin-eosin stanings and panels B, D and F show NESP55 immunoreactivity. Panels B and F are from sections consecutive to A and E, respectively. Symbols: asterisks: fibro-vascular stroma, arrowheads: indicate a group of three NESP55 immunoreactive cells, arrows: indicate a large tumor cell lacking NESP55 immunoreactivity.