Linear Control Theory for Gene Network Modeling
Figure 5
(a) Block diagram of a feedback loop and its simplified equivalent form. (b) Block diagram of negative autoregulation (NAR) and positive autoregulation (PAR). (c) The effect of H on the stability and behavior. NAR speeds up the response time of the gene expression and decreases the steady state value. In contrast, PAR increases both the response time and steady state value. (d) Simulation results. SR stands for simple regulation. The effects of NAR and PAR on the response time and steady state value are shown.