Downstream Gene Activation of the Receptor ALX by the Agonist Annexin A1
Figure 5
A) Gene expression of SGPP2, JAG1 and JAM3 in ALX-HEK293 transfected cells compared to empty vector-transfected cells (CMV group). B) Gene expression of SGPP2 in human peripheral mononuclear cells (PBMC) and polymorphonuclear cells (PMN), under control conditions (Ctrl) or after 4 h incubation with 0.5 µM AnxA1 (AnxA1). C) mSGPP2 gene expression in lymph nodes and thymuses of wild type (WT) and AnxA1null mice. (*p<0.05, t-Test compared to controls (A,B) or wild type (C)).