Olprinone Attenuates the Acute Inflammatory Response and Apoptosis after Spinal Cord Trauma in Mice
Figure 9
Effects of olprinone on TUNEL-like staining in the perilesional spinal cord tissue and S100β expression.
At 24 h after the trauma, SCI mice demonstrated a marked appearance of dark brown apoptotic cells and intercellular apoptotic fragments (B and B1). In contrast, tissues obtained from mice treated with olprinone (0,2 mg/kg) demonstrated no apoptotic cells or fragments (C). The number of TUNEL positive cells/high-power field was counted in 5 to 10 fields for each coded slide (D). Figure is representative of at least 3 experiments performed on different experimental days.