Hepatic Gene Expression Profiling Reveals Key Pathways Involved in Leptin-Mediated Weight Loss in ob/ob Mice
Figure 4
Gene Ontology tree representing the cellular compartments enriched by upregulated and downregulated set of genes.
Gene ontology analysis was performed using the GOTree Machine software which performs the hypergeometric test to evaluate the significance of enrichment for each category by determining if the observed number of gene counts exceeded the expected counts. Among the cellular compartments mitochondrion and endoplasmic reticulum are enriched by downregulated genes and vacuole, vesicle, lysosome are significantly enriched by upregulated genes.