Thyroid Hormone May Regulate mRNA Abundance in Liver by Acting on MicroRNAs
Figure 1
Serum T4 levels and liver malic enzyme mRNA levels in mouse pups rendered hypothyroid by 3 day exposure of dams and their litters to drinking water containing MMI and perchlorate from PND 12 to 15.
A. Serum T4 data are expressed as mean ± standard error (SE, n = 10) and * indicates significant difference (p<0.001). B. qRT-PCR for malic enzyme mRNA (positively regulated by direct TH action) was performed with RNA derived from male pups. Data are presented as mean ± SE (n = 5). A two-tailed Student's t-test was used to calculate significance and * indicates p = 0.03.