Transgenic Overexpression of Active Calcineurin in β-Cells Results in Decreased β-Cell Mass and Hyperglycemia
Figure 3
Transgenic mice expressing calcineurin showed altered insulin secretion.
A. Glucose stimulated insulin secretion in vivo assessed by intraperitoneal glucose injection. B. Static Insulin secretion in isolated islets from 8–12 week old WT and caCnRIP mice. C. Insulin secretion assessment by islet perifusion experiments with low (2 mM) and high (25 mM) glucose in islets from WT and caCnRIP mice (n = 3). Data expressed as mean ± SEM. *p<0.01.