Conformational Determinants of Phosphotyrosine Peptides Complexed with the Src SH2 Domain
Figure 7
Conformational trends of the pYVNV and pYENI complexed with the Src SH2 domain.
(left) Backbone representations of the 50 replicas (red) superimposed on the crystal structure of the pYVNV-ThrEF1Trp Src SH2 domain complex and the modeled extended conformation of pYVNV for (A) pYVNV and (C) pYENI. (right) Backbone of the representative structure of the main cluster (red) and minor cluster (pink) with the side-chain of residue Asn(pTyr+2) for (B) pYVNV and (D) pYENI. Backbone of SH2 domain in black, modeled extended conformation of pYVNV in yellow, β-turn conformation of pYVNV in blue.