Lamin A Rod Domain Mutants Target Heterochromatin Protein 1α and β for Proteasomal Degradation by Activation of F-Box Protein, FBXW10
Figure 4
Restoration of HP1β after treatment with proteasomal inhibitors.
HeLa cells transiently transfected with lamin constructs were treated with 6 µM MG132 or 10 µM lactacystin and stained with antibodies to HP1β. Arrows indicate transfected cells showing restoration of HP1β. Bar, 10 µM.