Phospholipase D1 Mediates TNFα-Induced Inflammation in a Murine Model of TNFα-Induced Peritonitis
Figure 4
TNFα-induced peritoneal cytokine/chemokine levels.
TNFα-induced changes in serum levels of: IL-6 (A); MIP-1α (B), and MIP-1β (C) levels in control mice (Basal); in mice injected with TNFα (TNF); in mice pretreated with the siRNA-PLD1 prior to TNFα administration (siRNA-PLD1+TNF); and in mice pretreated with the scrambled siRNA prior to TNFα administration (Scr-siRNA+TNF). Data showed as means ± SD of triplicate measurements from three different experiments. Student's t test p values (*p<0.05, **p<0.01). Six mice were used per treatment group per experiment.