T- and B-Cell-Mediated Protection Induced by Novel, Live Attenuated Pertussis Vaccine in Mice. Cross Protection against Parapertussis
Figure 6
Protection by purified CD4+ T cells from BPZE1-immunized mice.
Purified CD4+ or CD8+ T cells from BPZE1-immunized BALB/c mice (a) were transferred intraperitoneally to naïve SCID mice 24 h before they were intranasally infected with virulent B. pertussis BPSM. The mice were sacrificed 8 days later, and CFUs present in the lungs were counted (b). The results are expressed as means of log CFU values per lung from 5 mice per group (± standard error) and are representative of two independent experiments.