SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas
Figure 5
List of known direct SOX2 targets in hESCs that significantly correlate and anti-correlate to with SOX2 expression in lung SCCs.
A. The 71 genes that are known SOX2-activated target genes in human ESCs and significantly correlate with SOX2 expression in lung SCCs. B. The 26 genes that are known SOX2-repressed target genes in human ESCs and significantly anti-correlate with SOX2 expression in lung SCCs. Panels A and B: For each gene in each sample, expression is represented by a square with a color that codes for the level as a gradient (dark blue, low expression, to dark red, strong expression). C. Genmapp view of the enriched cell cycle regulators that are targets of SOX2 in hESCs and correlate with SOX2 expression in lung SCCs. Green boxes represent the genes that are significantly enriched among the known SOX2-activated target genes in human ESCs and correlate to SOX2 expression in lung SCCs.