Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma
Figure 5
Effect of PDGF and VEGF receptor kinase inhibitors on vessel leakage.
Evans blue was injected into the blood stream of tumor bearing mice. The dye in the tumor tissue was extracted and determined spectrophotometrically at 600 nm. The result was presented as the amount of Evans blue [4] extracted from dry weight of the tumor tissue (mg) and divided by the amount of Evans blue [4] present in the 1 µl of serum. Data are presented as means +/− SEM. Statistically significant differences (p<0.05) compared to vehicle treatment (*) are indicated.