Stereotaxical Infusion of Rotenone: A Reliable Rodent Model for Parkinson's Disease
Figure 3
Effects of ST infusion of rotenone on SNc oxidative stress levels.
(1) Dose response: the rats were sacrificed on the fourth week following the ST infusion of different doses (3-, 6-, or 12-µg) of rotenone, and the GSH activity (Figure 3A), SOD activity (Figure 3C), and MDA level (E) in the midbrain on the left and right sides were spectrophotometrically measured. (2) Time response: The animals infused with 3-µg rotenone were sacrificed on the second, fourth, sixth, and eighth week for the GSH, SOD, and MDA determination. *P<0.05, as compared to contralateral side. Data were expressed as the means±SD (n = 6).