Lipid Alterations in Experimental Murine Colitis: Role of Ceramide and Imipramine for Matrix Metalloproteinase-1 Expression
Figure 1
Increase of ceramide and decrease of LPC in chronic DSS-induced colitis.
(A–C) Lipid analysis of isolated colonic IEC by tandem mass spectrometry (control n = 12, 3% DSS n = 10). (A) Proportion of ceramide and LPC of analysed lipids. (B) Proportion of PC and FC of analysed lipids. (C) Proportion of SM, PE and PE-pl of analysed lipids. (D) Histological score. (E) Surface expression of epithelial cell marker, determined by flow cytometry after staining of the cells with FITC-labelled anti G8.8 antibodies. (**p<0.01, ***p<0.001)