Caspase-12 and the Inflammatory Response to Yersinia pestis
Figure 4
In-vitro cytokine measurements after PBMC stimulation with Yersinia enterocolitica, Yersinia pseudotuberculosis and Yersinia pestis.
Caucasian individuals bearing a normal (NOD2 wt, N = 10) or homozygous for the 3020insC NOD2 mutation (NOD2 del, N = 5) were stimulated with the various Yersinia spp. TNF (A) and IL-1β (B) were measured by ELISA after 24-hour stimulation. Values represent mean + SD for each group of volunteers. P-values for differences between caspase-12 genotype were calculated with the Mann-Whitney test. *P<0.05, **P≤0.01.