Caspase-12 and the Inflammatory Response to Yersinia pestis
Figure 3
In-vitro cytokine measurements after whole blood stimulation with Yersinia enterocolitica, Yersinia pseudotuberculosis and Yersinia pestis.
TNF (A), IL-1β (B) and IL-10 (C) were measured by ELISA after 24-hour stimulation. Volunteers were grouped as homozygous bearing the nonfunctional caspase-12 genotype (S/S), heterozygous bearing the functional caspase-12 and nonfunctional (S/L) and homozygous that bear the functional caspase-12 (L/L). The numbers of volunteers included for each cytokine are S/S = 24, S/L = 22 and L/L = 1. Values represent mean + SD for each group of volunteers. P-values for differences between caspase-12 genotype were calculated with the Mann-Whitney test.