Chronic Citalopram Administration Causes a Sustained Suppression of Serotonin Synthesis in the Mouse Forebrain
Figure 2
Effect of chronic citalopram treatment on forebrain 5-HT content.
A. 5-HT forebrain content in mice treated chronically with CIT or vehicle. 5-HT content was not significantly affected by CIT treatment at any single time point (p>0.05, Bonferroni post-ANOVA test). However, CIT treatment caused a significant overall reduction in 5-HT as determined by ANOVA (p<0.05). Numbers of mice: 2-day CIT-treated, n = 8; 2-day SAL-treated, n = 8; 2-week CIT-treated, n = 8; 2-week SAL-treated, n = 9; 4-week CIT-treated, n = 7; 4-week SAL-treated, n = 7. B. 5-HT forebrain content in mice treated chronically with CIT or vehicle and acutely with NSD-1015 (100 mg/kg IP) 30 minutes before sacrifice. Forebrain 5-HT content was reduced in mice treated with CIT for 2 weeks (*p<0.01, Bonferroni post test) and 4 weeks (*p<0.01) but not 2 days (p>0.05). Numbers of mice: 2-day CIT-treated, n = 6; 2-day SAL-treated, n = 6; 2-week CIT-treated, n = 8; 2-week SAL-treated, n = 7; 4-week CIT-treated, n = 7; 4-week SAL-treated, n = 10.