Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
Figure 3
Aged Pink1−/− brain contains decreased dopamine amount.
HPLC analysis of Pink1−/− striatal homogenates detected a significant reduction of dopamine (DA) at 9 and 22–24 months of age (n = 8 for each group).