A Cytokine–Cytokine Interaction in the Assembly of Higher-Order Structure and Activation of the Interleukine-3:Receptor Complex
Figure 4
Protein–protein interactions at interface II.
(A) A zoom-out view of the interface showing the secondary structural elements of IL-3 and the receptor involved in the reaction. The interaction between Glu22 of IL-3 and a number of aromatic residues from the receptor beta subunit (Tyr39, Tyr365, His367, Tyr421) is shown. (B) A zoom-in view showing additional details of interface II, including the interactions between Met19, Ile77 and Ala73 of IL-3 and Ser102, Val104, Val105 and Thr106 on the receptor beta subunit.