Vandetanib (Zactima, ZD6474) Antagonizes ABCC1- and ABCG2-Mediated Multidrug Resistance by Inhibition of Their Transport Function
Figure 4
Effect of vandetanib on the blockade of AKT and ERK1/2 phosphorylation.
KB-3-1 (A), C-A120 (B), S1 (C) and S1-M1-80 cells (D) were treated with vandetanib at indicated concentrations for 24, 48, or 72 h. The expressions of AKT, pAKT, ERK1/2 and pERK1/2 were examined by Western blot analysis, with GAPDH as the loading control as described in “Materials and Methods”. Independent experiments were performed at least three times and result from a representative experiment is shown.