Mechanisms Controlling Anaemia in Trypanosoma congolense Infected Mice
Figure 11
Erythrocyte degradation and leukocyte abundance.
Blvra and Hmox1, which are involved in erythrocyte degradation, increased dramatically after infection but then declined to near baseline by day 17. Cd14 and Cd45 (Ptprc) are markers of macrophage and leukocyte abundance respectively. Macrophages are the main cells involved in haemolysis and it appears that expression of Blvra and Hmox1 was correlated with macrophage abundance. C57BL/6 did not have consistently higher expression of any of these genes, suggesting that higher or more chronic haemolysis is not the cause of the more chronic anaemia of this strain.