A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide
Figure 2
Degradation of Hst-5 by C. albicans over time (minutes) demonstrating degradation level proportional to exposure time.
(A) Minor degradation following 20 mins incubation at 37°C observed by the appearance of lower weight product, whereas significantly increasing level of degradation seen following 1 h and 2 h incubation (B) Decrease in the percent of Integrated Density Value (IDV) of the intact Hst-5 (upper band) (P<0.0001) and increase in the IDV of the degradation product (lower band P<0.02) MW: molecular weight ladder.