Neurogenin2 Directs Granule Neuroblast Production and Amplification while NeuroD1 Specifies Neuronal Fate during Hippocampal Neurogenesis
Figure 9
Model of postnatal hippocampal granule neurogenesis.
Multipotent GFAP/Nestin/Pax6/Glast+ radial glia stem cells give rise to multipotent and highly dividing Pax6/Mash1+ progenitors. Ngn2 initiates neuronal commitment of Pax6/Mash1+ progenitors. Ngn2 progenies undergo asymmetric divisions and amplify until they divide symmetrically and express NeuroD1. NeuroD1 stops the amplification phase of Ngn2 progenies and direct neuronal maturation. NeuroD1 progenies undergo maturation through the expression of the transcription factors Tbr1, NeuroD2 and Prox1 and the cellular markers Dcx, PSA-NCAM, Calretinin and NeuN.