Outline of a Genome Navigation System Based on the Properties of GA-Sequences and Their Flanks
Figure 1
Typical appearance of the GPxI of the GA-complexes ( = upstream flank of 400 [b]+GA-sequence+downstream flank of 400 [b]) of human chromosomes.
The GA-complexes are vertically aligned with the upstream ends of their GA-sequences. While the ends of all upstream flanks are automatically aligned, because they extend the same distance from the GA-sequences, the ends of the downstream flanks are not and appear frayed, as the length of each GA-sequence varies. The aligned GA-sequences in their natural order of occurrences in the chromosome are labeled as ‘GA-ribbon’. a. GPxI of the first 1000 GA-complexes of human chr.1 in their natural order of occurrence in the chromosome. Note the appearance of the ‘upstream stripes’ (see text) in the aligned upstream flanks and the predominantly black ( = poly-A) upstream beginnings of the aligned GA-sequences.(Scale: 50 [b]/division). b. Enlargement of the frame shown in panel a. Arrow points to the border between upstream flank and GA-sequence. By definition, it consists of T’’s or C's. (Scale: 50 bases).