Memory Extinction Entails the Inhibition of the Transcription Factor NF-κB
Figure 6
The reinstatement with 10 trials reveals the original memory over sulfasalazine-induced amnesia in memory reconsolidation.
A. Experimental design: On day 1 the animals were trained with 15 trials (TR groups) in the context A or were located in the context but remained untrained (CT groups). On day two, a pair of CT-TR groups was injected with 6 μg/g sulfasalazine and the other with vehicle solution (indicated with arrows). 20 min later, all groups were re-exposed to the context A for 5 minutes. 48 h after re-exposure session the groups were reinstated with 10 trials in the context B. 24 h later all groups were tested for memory retention with one trial in the context A. B. Performance at testing session. C. Experimental design: On day 1 the animals were trained with 15 trials (TR groups) in the context A or were located in the context but remained untrained (CT groups). On day two, a pair of CT-TR groups was injected with 6 μg/g sulfasalazine and the other with vehicle solution (indicated with arrows). 20 min later, all groups were re-exposed to the context A for 5 minutes. 48 h after re-exposure session the groups were exposed to the context B for 30 minutes. 24 h later all groups were tested for memory retention with one trial in the context A. D. Performance at testing session. Values are Mean Response Level±SEM at testing. *, p<0.05.