MyD88 Dependent Signaling Contributes to Protective Host Defense against Burkholderia pseudomallei
Figure 6
Enhanced liver damage in MyD88 KO mice.
Representative hematoxylin- and eosin-stained liver histology slides for WT (A) and MyD88 KO (B) mice at 72 h after inoculation with 5×102 CFU B. pseudomallei show more inflammation and foci of necrosis (as indicated by the asterisk) in the livers derived from MyD88 KO animals compared to WT controls (original magnification, ×400) corresponding with higher pathology scores (see Methods section) (C). At 72 h after inoculation MyD88 KO mice also showed enhanced hepatic injury, as reflected by the plasma concentrations of aspartate aminotransferase (ASAT) (D) and alanine aminotransferase (ALAT) (E). Data are mean±SEM (n = 5–6 per group); U/L, units per liter; * P<0.05; ** P<0.01.