A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol
Figure 1
The inhibitory effect of menthol on synaptically driven spiking in hippocampal cultures.
(A) Typical traces of spontaneous spiking from one cell in the presence or absence of menthol. (B) Typical traces of zero Mg2+-induced spiking from the same cell in the presence or absence of menthol. (C) The distribution of interspike interval obtained from A and B showing the effect of menthol on spontaneous spiking and elevated spiking. (D) Concentration-dependent inhibition of menthol on spontaneous and zero Mg2+-induced firing rate. (n = 6).