Substantial Alterations of the Cutaneous Bacterial Biota in Psoriatic Lesions
Figure 4
DPCoA of SLOTU relatedness in 39 human skin samples obtained from healthy subjects and psoriatic patients.
The healthy subjects were designated A–F, and at each sampling both left (L) and right (R) forearm skin was examined. In four subjects, new specimens were obtained 8–10 months later (e.g. designated AL2). The psoriatic patients were designated 1, 2, 3, 4, 6, and 8, PN indicates that sample is from uninvolved skin and PP is from psoriatic lesions. In a representation of the first two orthogonal principal axes, based on a sample dissimilarity matrix, samples from the same subjects at the same time point are plotted by using the same color, and the normal skin and psoriatic lesion samples are indicated by thin and thick circle walls, respectively. The size of each circle is proportional to the sample's Rao diversity index. The scale (bottom right) indicates the relative diversity of the populations within the circles, with the test sample of smallest diversity (2PN) indexed as 1.0.