Conceptual Modeling in Systems Biology Fosters Empirical Findings: The mRNA Lifecycle
Figure 6
Zooming into Post-ribosomal Processing.
(A) Zooming into Post-ribosomal Processing exposes its subprocesses Checkpoint, Storing, and Degradation, as well as the objects D-factor and Decision. As before, red indicates uncertainty or hypothesis: We propose that D-factor is the instrument for the process we call Checkpoint, which in turn, determines whether to store, degrade, or unload the mRNA for reuse. Green links denote an uncertain conjecture that was confirmed in this work by our experiments. Here, the structural link from P Body to eRF3 and the tag contains along it are green, denoting that we demonstrated experimentally our model-based conjecture that P-body contains eRF3. (B) The OPL text of the OPD in (A). Note the red color of the words in the sentences Checkpoint requires D-factor. and in Checkpoint yields Decision. The red denotes that we are not certain whether Checkpoint and D-factor exist, and if so whether Checkpoint requires D-factor. On the other hand, the green color of the word contains in the sentence P-body contains eRF3 indicates our success at experimentally proving our model-based conjecture that P-body contains eRF3.