Large Scale Comparative Codon-Pair Context Analysis Unveils General Rules that Fine-Tune Evolution of mRNA Primary Structure
Figure 6
Some codon-pair context patterns are associated to mRNA primary structure biases.
A) In order to identify ORFeome specific codon-pair context biases the two large scale context maps were filtered in such a way that only cells that yielded residual differences above 15 between the ORFeomes and total genomes sequences were shown. All other cases were colored in black (see Figure S5 for different display thresholds). Codon-pair context patterns specific of ORFeomes are highlighted on the side of panel A. B) To visualize the patterns that appear in genomes and are absent in ORfeomes, large-scale comparative maps obtained with total genomes and ORFeomes were subtracted and only the cells that yielded differences above 15 were displayed. This highlighted patterns that are strongly preferred or repressed in coding sequences and may correspond to mistranslation hot spots.