Metabolomic landscape of macrophage discloses an anabolic signature of dengue virus infection and antibody-dependent enhancement of viral infection
Fig 8
Other metabolite variants produced by dengue virus infection.
A: heatmap of differentially expressed other metabolites covering benzenoids, benzoic acids, bile acids, eicosanoids, imidazoles, indoles, nucleotides, peptides, phenols, phenylpropanoic acids, and pyridines. The mean Z-score of sextuplicate in each group was shown. B: display of other metabolite variants by DENV infection only or ADE infection in comparison with non-viral infection. The mean density of sextuplicate of each variant was shown. Blue dot: significantly decreased variants; red dot: significantly increased variants. C: distribution of significant other metabolite variants under different infection conditions. D: purine nucleoside monophosphates impact multiple anabolic signaling pathways. Ctr: non-viral infection control.