Enantiospecific antitrypanosomal in vitro activity of eflornithine
Fig 2
The overall antitrypanosomal in vitro activity was elicited by the more active L-eflornithine enantiomer.
Antitrypanosomal activity for racemic eflornithine (blue), L-eflornithine (green) and D-eflornithine (red) against three T.b. gambiense strains collectively. Parasite growth values are shown as relative fluorescence in the AlamarBlue serial drug dilution assay. Dots represent observed experimental data, lines the model predictions and grey areas the 5th to 95th percentiles of the model prediction central values.