An investigation into the role of chronic Schistosoma mansoni infection on Human Papillomavirus (HPV) vaccine induced protective responses
Fig 5
Illustrates the average number of cells that have lost any level of CFSE labelling after 72 hours in culture during specific (HPV, SEA and SWAP), non-specific stimulation (CONA) and absence of stimulant (MED) in Schisto-infected+HPV, Schisto/PZQ+HPV and HPV-only (Control) groups. PBMCs were collected from the 3 groups at 4 time points; Week 0 (pre-vaccination), Week 4 (4 weeks after the 1st vaccination and before the booster), Week 6 (6 weeks after the 1st vaccination and 2 weeks after the 2nd dose), Week 8 (8 weeks after 1st dose and 4 weeks after 2nd dose). The bars represent the mean number of CFSElow PBMCs of each group at each time point. Data was normalized according to the baseline results (Week 0) and analyzed using one-way ANOVA followed by Dunn multiple comparison test. Data was considered statistically significant if p≤0.05 and assign *** p = 0.0006.