The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy
Fig 1
M. leprae infection leads to induction of cell fate pathways in MDMs.
(A). Heatmap of clustered genes induced by M. leprae at different time points. Color green indicates downregulated genes and color red indicates upregulated genes. (B). Top Canonical Pathways significantly enriched in the M. leprae induced-gene signature by IPA core analysis. (C). Most expressed upstream regulators by fold-change (FC) in the M. leprae induced-gene signature. (D). IPA Disease and Functions analysis of the M. leprae induced-gene signature. The p-value is calculated by Fisher’s Exact Test and measures the significant overlap between the dataset genes and the genes that belong to a canonical pathway, upstream regulator or the ‘Disease and Function’ categories in the IPA knowledge database. Adjusted p-values (padj) were calculated using Bonferroni correction. Ratios represent the number of genes in the dataset that appear in an IPA term divided by the total number of genes of the same term. Genes of the canonical pathway, upstream regulator or ‘Disease and Functions’ analyses were selected based on their functional relevance and displayed in boxes. # genes represent the exact number of molecules in our dataset regulated by an upstream regulator or found in the Disease and Functions categories.