The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy
Fig 5
Evaluation of in vivo infection by L. amazonensis.
C57BL/6 WT and TLR9-/- mice were infected in the right hind paw with 5×105 L. amazonensis promastigotes (Josefa strain). A, C. The lesion sizes were measured on the indicated days and expressed as the difference of thickness between non-infected and infected paws. B. Parasite load was measured after 120 days of infection (dpi) or D. 67 dpi and expressed as the mean number of parasites per paw (mean ± SD; n = 4–5) *P ≤ 0.05. Results representative of three independent experiments.