Albendazole increases the inflammatory response and the amount of Em2-positive small particles of Echinococcus multilocularis (spems) in human hepatic alveolar echinococcosis lesions
Fig 1
Immunohistochemical analysis of sections of liver tissue from patients with E. multilocularis infection without ABZ treatment (n = 8), < two months’ (n = 5) and > two months’ treatment with ABZ (n = 7).
EM2G11 staining shows an increase in spems from sections without treatment as compared to stainings of samples with treatment up to two months and a decrease in > two months’ treatment. (A: Case #3, B: Case #11, C: Case #19, bar = 500μm) CD20 staining illustrates an increase in B cells during treatment. (A: Case #7, B: Case #12, C: Case #19, bar = A: 200μm, B, C: 500μm) CD38 staining shows an increase in plasma cell content with a maximum in < two months of ABZ treatment. (A: Case #6, B: Case #9, C: Case #17, bar = 200μm) CD4 staining reveals an increase in the number of CD4+ T cells in the tissue after treatment for > two months. (A: Case #3, B: Case #13, C: Case #18, bar = 200μm) FGL2 staining shows a decrease in the number of FGL2+ cells with a minimum at < two months of treatment. (A: Case #7, B: Case #12, C: Case #18, bar = 200μm).