Analgesic Effect of Photobiomodulation on Bothrops Moojeni Venom-Induced Hyperalgesia: A Mechanism Dependent on Neuronal Inhibition, Cytokines and Kinin Receptors Modulation
Fig 4
Effect of LLLT on kinin receptor mRNA expression.
mRNA levels of B1 (A) or B2 (B) kinin receptors were evaluated by RT-PCR on footpad samples of the mice injected intraplantar with saline or Bmv (1 μg) and treated or not with LLLT 685 nm at or antivenom (AV) or a combination of LLLT and AV. Samples were collected 6 h after saline or Bmv injection. Experiments were performed in triplicates. Data are expressed as means ± SEM of 5 animals from each group. Statistically significant differences vs. saline (#p<0.05) or vs. Bmv (*p<0.05) or vs Bmv + AV (&p<0.05) are indicated.