Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever
Fig 5
Receiving Operating Curve of combined serum serotonin and IFN-γ.
Values indicate prediction performance for DHF. Green, serotonin only; blue, IFN-γ only; yellow, platelets only and red, serotonin and IFN-γ. The receiver operating characteristic (ROC) curve plot is a plot of the true positive rate (sensitivity) against the false positive rate (1—specificity) for the different possible cutpoints of a prognostic test, and provides a useful metric to compare different indicator variables (biomarkers). An area under the ROC curve (AUC) value close to 1 indicates an excellent prognostic test, a curve that lies close to the diagonal (AUC = 0.5) has no information content and therefore no prognostic utility. Amongst various sera metabolites and cytokines, the highest AUC value (0.92) was the combination of serotonin and IFN-γ.