Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine
Fig 4
Oxamniquine enantiomers bound to the SmSULT active site.
A) 1.8 Å electron density calculated with coefficients 2mFo-DFc contoured at 1.0σ superimposed on the refined structure of the R-OXA•SmSULT•PAP complex. Numbers represent H-bond lengths in Å. B) 1.3 Å electron density calculated with coefficients 2mFo-DFc contoured at 1.0σ superimposed on the structure of the S-OXA•SmSULT•PAP complex. Note: some structural elements have been removed for clarity.