High Fat Diet Modulates Trypanosoma cruzi Infection Associated Myocarditis
Figure 7
Immunoblot analysis of the WAT confirmed T. cruzi infection induced systemic alterations in lipid/cholesterol homeostasis.
WAT from both the RD and HFD fed infected mice showed upregulated LDLr, Abca1 and LPL activity. Unlike hearts from the infected mice WAT showed no multimer adiponectin and also significantly reduced adiponectin monomers. Fold change in the protein levels were normalized to GDI expression and represented as bar graph (n = 5, p≤0.005). Bars represent mean values of the data with SEM as vertical lines. Significant change is represented by black stars compared with uninfected RD mice. Significant difference between infected RD and infected HFD is represented by white stars (p≤0.005).