Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders
Figure 2
Plasmatic levels of chemokines and cytokine ratios among HTLV-1-infected patients with skin lesions.
Serum chemokines and cytokines quantitation were performed by CBA as described in materials and methods. The results are expressed as concentration in pg/mL (×103) ± standard error of (A) CCL2, (B) CCL5, (C) CXCL8, (D) CXCL9, (E) CXCL10 in the serum of HTLV-infected patients and controls with infectious (L(INF) = dark gray rectangles) and autoimmune (L(AI) = black-gray rectangles) skin lesions as well as carriers and controls without skin lesions (L(−) = light gray rectangles). Significant differences at P<0.05 are highlighted by letters for difference of a group as compared to control L(−) indicated by “a”, to control L(INF) indicated by “b”, to control L(AI) indicated by “c”, to HTLV-1+ L(−) indicated by “d” and to HTLV-1+ L(INF) indicated by “e”. The ratio between cytokines and IL-10 for all groups was calculated for (F) IL-1β, (G) IL-6, (H) IL-12, (I) TNF-α. Significant differences are highlighted by connecting lines.