The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway
Figure 1
Sequence and overall structure of LmTXN.
A. X-ray structure of the monomer. B. Sequence alignment of LmTXN, CfTXN and TbTXN. The alignment was performed with the program CLUSTALVIEW-MULTIALIGN (http://mobyle.pasteur.fr/cgi-bin/portal.py#forms::clustalw-multialign). The secondary structure elements are indicated (α: α-helices, θ: 310-helices, β: β-strand), α0 refering only to LmTXN. Asterisks indicate identical residues in the three sequences while “.” and “:” indicate “similar” and “more similar” residues as defined by the CLUSTALVIEW program. The residues of the catalytic loop are indicated. The residues in position 9 belonging to the α0 helix are also indicated in the figure.