Comparative Expression Profiling of Leishmania: Modulation in Gene Expression between Species and in Different Host Genetic Backgrounds
Figure 1
Expression profiling of gene subsets from three Leishmania genomes.
Scatter plots (generated using Microsoft Excel) show the distribution of log2 fold changes in RNA expression levels against their statistical significance (−log2 p-value) for up to 785 genes per genome. Fold change of >1.7 between data points (dashed horizontal lines); significant p-value<0.05 (dashed vertical lines). (A) L. braziliensis amastigotes vs. procyclics; (B) L. braziliensis amastigotes vs. metacyclics; (C) L. braziliensis metacyclics vs. procyclics; amastigotes of (D) L. braziliensis vs. L. major, (E) L. braziliensis vs. L. infantum, (F) L. major vs. L. infantum; (G) L. major amastigotes from BALB/c vs. Rag2−/−γc−/− mice.