Vascular Endothelial Growth Factor Mediates Intracrine Survival in Human Breast Carcinoma Cells through Internally Expressed VEGFR1/FLT1
Figure 7
Localization of VEGFR1 in MCF-7 and MDA-MB-231 Cells
Cells were stained with anti-VEGFR1 and anti-LMNA (Lamin A/C; a nuclear envelope marker) antibodies. Localization of VEGFR1 was then examined using confocal microscopy. LMNA was specifically localized at the nuclear envelope. Strong VEGFR1 protein expression was observed in the nuclear envelopes of the MCF-7 and MDA-MB-231 cells. Merged staining shows colocalization of VEGFR1 and LMNA at the nuclear envelopes.