The Cross-Regulation Between Set1, Clr4, and Lsd1/2 in Schizosaccharomyces pombe
Fig 7
A model depicting the cross-regulation between CLRC, COMPASS, and Lsd1/2 proteins.
We propose that CLRC functions as a ubiquitin E3 ligase that potentially targets Lsd1/2 or Set1 and promotes their degradation. Set1 safeguards Lsd1/2 from degradation by methylating the specific lysine residues of Lsd1/2, which competes with ubiquitination from CLRC.