Phosphorylation of AHR by PLK1 promotes metastasis of LUAD via DIO2-TH signaling
Fig 8
T4 secreted by thyroid glands of LUAD patients enters the circulation system and reaches the local environment of tumors. Phosphorylation of AHR by PLK1 elevates DIO2, which converts the less potent T4 to more potent T3. T3 activates the TH signaling and promotes EMT. Mesenchymal-like tumor cells are prone to local invasion and distant metastasis. Created with BioRender.com.