Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia
Fig 5
Functional profiling of GS height preserved modules with cumulative evidence for genomic risk effect on co-expression.
Similar functional divergence in biological processes enrichment like GS-SCZ preserved modules: transcription, translation and metabolic ontologies are enriched in gene sets originated from modules with MEs positively correlated with GS-SCZs SCZ; nervous system development and functionality ontologies are enriched in gene sets originated from modules with MEs negatively correlated with GS-SCZs SCZ (highlighted by red rectangles). In addition, one set from GS3-Ht preserved lightgreen module negatively correlated with genomic scores of height was enriched in synapse related GO:BP. Legend: BG_GS3_ / BG_GS5_x = fragments from height GS3 or GS5 preserved modules overlapped with background (BG) modules.