Restoration of energy homeostasis under oxidative stress: Duo synergistic AMPK pathways regulating arginine kinases
Fig 9
A schematic diagram illustrating the proposed AMPK/AK pathways maintaining ATP homeostasis under oxidative stress.
Activation of AMPK increases the transcription level of TcAK1 and TcAK2 via phosphorylating FOXO and promoting its nuclear translocation. AMPK can also directly phosphorylate TcAK1 and TcAK2 to change their catalytic activity for rapid production of ATP.